TweetDeck is one of the best Twitter client. It is an Adobe AIR application.It also connecting you with your contacts across Facebook, MySpace, LinkedIn, Foursquare, Google Buzz and more like realtime browser. It also supports Groups
Seesmic is also one of the best Twitter client. It is a silverlight application.It also lets us use our Facebook account. With seesmic you can manage and post from multiple Twitter accounts
Twhirl
Twhirl is a free twhirl is a social software desktop client, based on the Adobe AIR platform. This small AIR based application compatible with Windows systems from 2000 to 7, packs a lot of features within.It supports cross-post your updates to Jaiku and many other sites like Facebook, MySpace, LinkedIn and more via Ping.fm
Spaz is a desktop Twitter and Identi.Ca and Laconi.Ca client. It is also an Adobe AIR application.This is Written in pure Javascript, XHTML and CSS. Utilizes the powerful jQuery Javascript framework.
